Emily Sharp

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The activity of L-type Ca2+ channels is increased by dihydropyridine (DHP) agonists and inhibited by DHP antagonists, which are widely used in the therapy of cardiovascular disease. These drugs bind to the pore-forming alpha1 subunits of L-type Ca2+ channels. To define the minimal requirements for DHP binding and action, we constructed a high-affinity DHP(More)
DNA from members of an Irish pedigree presenting with late onset autosomal dominant retinitis pigmentosa (ADRP) have been typed with a series of genetic markers from chromosome 6p. Positive two-point lod scores have been obtained with five markers (D6S89: theta = 0.10, Z = 3.338; D6S109: theta = 0.10, Z = 3.932; D6S105: theta = 0.00, Z = 6.081; HLA-DRA:(More)
A 42-year-old female teetotaller presented via the accident and emergency department with a 2-day history of vomiting and upper abdominal pain. She was diagnosed with acute pancreatitis. The aetiology of the pancreatitis was identified as hypercalcaemia secondary to oral calcium supplementation. The hypercalcaemia was corrected by stopping calcium(More)
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  • Michalski J R Ruff, S W Christensen, P R Cloutis, Kraft M D Rampe, E Sharp, T G Michalski +16 others
  • 2006
In this abstract, we discuss the infrared emission spectral characteristics of zeolite minerals — a potentially important group of minerals in chemical weathering environments on Mars. We are performing mineral mixing experiments to better understand the effects of thermal emission spectral mixing for spectra from weathered surfaces. Mineral spectra from(More)
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