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Interleukin-13 receptors on human prostate carcinoma cell lines represent a novel target for a chimeric protein composed of IL-13 and a mutated form of Pseudomonas exotoxin.
We have discovered a new cell surface protein in the form of interleukin-13 receptor on several solid tumor cells, including human renal cell carcinoma cells (Obiri et al., 1995; Debinski et al.,Expand
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Systemic interleukin 2 therapy for human prostate tumors in a nude mouse model.
Once the regional lymph nodes become involved in prostate carcinoma, 85% of patients develop distant metastases within 5 years, and metastatic disease is difficult to treat. We have investigated theExpand
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Local tumor irradiation augments the response to IL-2 therapy in a murine renal adenocarcinoma.
We have previously demonstrated that local tumor irradiation effectively enhanced the therapeutic effect of IL-2 therapy on pulmonary metastases from a murine renal adenocarcinoma, Renca. IrradiationExpand
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The mechanism of local tumor irradiation combined with interleukin 2 therapy in murine renal carcinoma: histological evaluation of pulmonary metastases.
We have demonstrated that tumor irradiation enhanced the therapeutic effect of interleukin 2 (IL-2) on pulmonary metastases from a murine renal adenocarcinoma, Renca. To investigate the mechanism ofExpand
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Effect of local tumor irradiation and interleukin-2 therapy in different murine tumors.
The combined effect of local tumor irradiation and systemic immunotherapy was investigated in different murine tumors. Pulmonary metastases were induced in C57BL/6 mice by intravenous injection ofExpand
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Systemic treatment with interleukin-4 induces regression of pulmonary metastases in a murine renal cell carcinoma model.
Advanced metastatic renal cell carcinoma has been shown to be responsive to immunotherapy but the response rate is still limited. We have investigated the therapeutic potential of systemicExpand
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Radiation-induced effects on murine kidney tumor cells: role in the interaction of local irradiation and immunotherapy.
Local tumor irradiation enhances the effect of interleukin-2 (IL-2) therapy in the Renca murine renal adenocarcinoma model. To investigate the mechanism(s) of this interaction, we studied the inExpand
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Expansion of Activated Lymphocytes Obtained from Renal Cell Carcinoma in an Automated Hollow Fiber Bioreactor
Immunotherapy using IL-2 alone or combined with activated lymphocytes has been promising for metastatic renal cell carcinoma. Cytotoxic lymphocytes can be isolated from tumors, expanded in vitro withExpand
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Inhibition of murine renal carcinoma pulmonary metastases by systemic administration of interferon gamma: mechanism of action and potential for combination with interleukin 4.
We have previously demonstrated that IFN-gamma causes cell growth inhibition and up-regulation of MHC antigens in human renal cell carcinoma cell lines. In this study, we have investigated theExpand
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Responsiveness of human prostate carcinoma bone tumors to interleukin-2 therapy in a mouse xenograft tumor model.
We have tested an immunotherapy approach for the treatment of metastatic prostate carcinoma using a bone tumor model. Human PC-3 prostate carcinoma tumor cells were heterotransplanted into the femurExpand
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