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Differences in the Regulation of K-Ras and H-Ras Isoforms by Monoubiquitination*
Background: Ras proteins are critical regulators of cellular growth and are differentially modified by ubiquitination. Results: Chemical ubiquitination and immunoprecipitation assays demonstrate thatExpand
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Site–Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function
Cell growth and differentiation are controlled by growth factor receptors coupled to the GTPase Ras. Oncogenic mutations disrupt GTPase activity, leading to persistent Ras signaling and cancerExpand
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TBK1 is a Synthetic Lethal Target in Cancer with VHL Loss.
TANK Binding Kinase 1 (TBK1) is an important kinase involved in innate immune response. Here we discover that TBK1 is hyperactivated by von Hippel-Lindau (VHL) loss or hypoxia in cancer cells. TumorsExpand
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Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase.
Thymidylate synthase (TS) catalyzes the production of the nucleotide dTMP from deoxyuridine monophosphate (dUMP), making the enzyme necessary for DNA replication and consequently a target for cancerExpand
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Mass spectrometry–based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells
The maternal embryonic leucine zipper kinase (MELK) has been implicated in the regulation of cancer cell proliferation. RNAi-mediated MELK depletion impairs growth and causes G2/M arrest in numerousExpand
Novel Sites of Gamma Carboxylation in Human Factor VII
Introduction Gamma- (γ-) carboxylation of glutamate residues is a vitamin K-dependent post-translational modification critical to the function of several plasma proteins. Found in the N-terminalExpand
Comparative Proteomics of Unactivated and Activated Peripheral Blood Eosinophils
Introduction Eosinophils play important roles in tissue homeostasis and the inflammation of allergic diseases such as asthma. Concomitant with extravasation into inflamed tissues, blood eosinophilsExpand
Reduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A/B′δ holoenzyme
Protein phosphatase 2A (PP2A) is a large enzyme family responsible for most cellular Ser/Thr dephosphorylation events. PP2A substrate specificity, localization, and regulation by second messengersExpand
Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA–NF-κB
Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of cancer therapy that frequently requires a reduction or cessation of treatments and negatively impacts the patient's qualityExpand