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Epstein-Barr virus (EBV) persists in the immune host by preferentially colonizing the isotype-switched (IgD(-)CD27(+)) memory B-cell pool. In one scenario, this is achieved through virus infection of naive (IgD(+)CD27(-)) B cells and their differentiation into memory via germinal center (GC) transit; in another, EBV avoids GC transit and infects memory B(More)
The performance of the ANIMAL (Automated Nonlinear Image Matching and Anatomical Labeling) nonlinear registration algorithm for registration of thoracic 4D CT images was investigated. The algorithm was modified to minimize the incidence of deformation vector discontinuities that occur during the registration of lung images. Registrations were performed(More)
Epstein-Barr virus (EBV), a lymphomagenic human herpesvirus, colonises the host through polyclonal B cell-growth-transforming infections yet establishes persistence only in IgD⁺ CD27⁺ non-switched memory (NSM) and IgD⁻ CD27⁺ switched memory (SM) B cells, not in IgD⁺ CD27⁻ naïve (N) cells. How this selectivity is achieved remains poorly understood. Here we(More)
In this work we present a method of calculating dose in deforming anatomy where the position and shape of each dose voxel is tracked as the anatomy changes. The EGSnrc/DOSXYZnrc Monte Carlo code was modified to calculate dose in voxels that are deformed according to deformation vectors obtained from a nonlinear image registration algorithm. The defDOSXYZ(More)
The delta opioid receptor (DOPr), whilst not the primary target of clinically used opioids, is involved in development of opioid tolerance and addiction. There is growing evidence that DOPr trafficking is involved in drug addiction, e.g., a range of studies have shown increased plasma membrane DOPr insertion during chronic treatment with opioids. The(More)
1. Abstract A positional game can be thought of as a generalization of Tic-Tac-Toe played on a hypergraph (V, H). We study the Maker-Breaker game in which Maker wins if she occupies all of the vertices in an edge of H; otherwise Breaker wins. The Erd ˝ os–Selfridge Theorem, a significant result in positional game theory, gives criteria for the existence of(More)
A new deformable geometry class for the VMC++ Monte Carlo code was implemented based on the voxel warping method. Alternative geometries which use tetrahedral sub-elements were implemented and efficiency improvements investigated. A new energy mapping method, based on calculating the volume overlap between deformed reference dose grid and the target dose(More)
The funicular part of the ligamentum nuchae of Bos indicus attaches to the dorsolateral edges of the bifid spines of the seventh thoracic through third lumbar vertebrate. Cranially, the funiculus nuchae runs freely medial to the deep thoracic fascia which separates it from the overlying rhomboideus thoracis. The zebu hump is composed primarily of(More)
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