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Stroke/brain ischemia is a leading cause of death and long-term disabilities. Increased oxidative stress plays an important role in the pathology of brain ischemia. Hydrogen peroxide (H(2)O(2)) is a major oxidant known to cause neuronal injury; however, the detailed mechanism remains unclear. Previous studies have suggested that H(2)O(2)-induced injury is(More)
A ctivation of the renin–angiotensin–aldosterone system (RAAS) has a central role in the pathophysiology of congestive cardiac failure. Increased concentrations of RAAS neurohormones are associated with worse outcomes in patients with heart failure. 1 Blockade of this system with angiotensin converting enzyme (ACE) inhibitors, b blockers, and spironolactone(More)
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