Emilio Erazo-Fischer

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We studied how afferent nerve activity affects the in vivo maturation of a fast glutamatergic CNS synapse, the calyx of Held. To address this question, we exploited the distinct presynaptic Ca2+ channel subtypes governing transmitter release at the cochlear inner hair cell (IHC)-spiral neuron synaptic junction compared with those at higher synapses along(More)
Voltage-gated Ca2+ channels (VGCCs) of the P/Q-type, which are expressed at a majority of mammalian nerve terminals, show two types of Ca2+-dependent feedback regulation-inactivation (CDI) and facilitation (CDF). Because of the nonlinear relationship between Ca2+ influx and transmitter release, CDI and CDF are powerful regulators of synaptic strength. To(More)
INTRODUCTION In Europe a disease is recognized as rare if less than 1 in 2000 people suffer from the specific disease. In patients with familial homozygous hypercholesterolemia (HoFH) the accumulation of low-density lipoprotein cholesterol (LDL-C) leads to generalized atherosclerosis due to an insufficient functioning of the LDL-C receptors. Patients die(More)
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