Emilio Agostoni

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The knowledge of pleural liquid pressure (Pliq) is essential for understanding the mechanical coupling between lung and chest wall and the liquid exchanges of the pleural space. In the last decade, research in this field contributed new ideas and stimulating controversies but also caused some confusion. These aspects, along with the older contributions, are(More)
The occurrence of a solute-coupled absorption of liquid from the pleural space was studied by measuring in anesthetized rabbits the volume of liquid of the right pleural space 1 h after injecting into it 2 ml of Ringer solution or of Ringer with an inhibitor of a Na(+)-Cl- coupled transport or of the Na+/K+ pump. Volume collected after Ringer was 1.56 +/-(More)
Diaphragm activity (Edi, 20 Hz low cutoff) was recorded with great time resolution to ascertain whether there is a discontinuity between its inspiratory and postinspiratory periods in humans. We first determined in anesthetized rabbits that gaps or notches in Edi occurred within 80 msec before and after the end of mechanical inspiration in 70% of the(More)
Moving average electromyography (MA) of quadriceps muscle bellies has been recorded during bicycling at different rates (30-70 cycles/min) or forces (1-3 kg). For power increments (50-100%) achieved by increasing force at constant rate, MA during pedal downstroke always increased. For similar power increments achieved by increasing the rate at constant(More)
In supine dogs with saline-filled lungs the vertical gradient of pleural surface pressure (VGPpl) was not significantly different from -1 cm H2O/cm and that of transpulmonary pressure (VGPtp) was not significantly different from zero. Hence the hydrostatic gradient of the liquid was entirely taken up by the chest wall, the ribs being rigid in the direction(More)
In anesthetized dogs and rabbits passive or active limb movements (1) shifted to the left the relationship between tidal volume (Vt) and inspiratory time (Ti), (2) lowered the relationship between expiratory time (Te) and Ti and decreased its slope, and (3) increased the output to the inspiratory muscles (Vt/Ti). These effects increased with increasing the(More)