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Synthesis and biological evaluation of novel imidazole-containing macrocycles
A new family of compounds made of a 5-aryl-1H-imidazole motif included in a macrocycle has been designed and synthesized. The synthesis of the imidazole core makes use of our previously developedExpand
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Planar Chirality of Imidazole-Containing Macrocycles - Understanding and Tuning Atropisomerism
The synthesis and characterization of imidazole-containing macrocycles displaying planar chirality has been achieved. HLPC and NMR studies revealed the crucial role of the alicyclic chain length inExpand
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The Synthesis of Two Regioisomeric Aldehydes with a Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions
The paper describes the synthesis of two regioisomeric 2-amino-3-formyl- and 3-amino-2-formyl-substituted derivatives of tetrahydrobenzo[ b ]thiophene and their subsequent thermally initiatedExpand
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Development of a general and regioselective N-alkylation strategy of azoles and synthesis of original imidazole derivatives of chemical and biological interest
Imidazoles are key structures in medicinal chemistry. Numbers of imidazole derivatives have found applications in the treatment of infectious diseases, cancer, metabolic, cardiovascular, and CNSExpand
Microwave initiated intramolecular cyclizations of in situformedazomethine ylide with allylamino group at substitutedthiophene
Synthesis of new pyrrolo[3,2-c]pyridine heterocycles by microwave induced cycloaddition reaction. The reaction is proceeding in two subsequent steps. The first is intermolecular reaction of secondaryExpand