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Synthesis and biological evaluation of novel imidazole-containing macrocycles
A new family of compounds made of a 5-aryl-1H-imidazole motif included in a macrocycle has been designed and synthesized. The synthesis of the imidazole core makes use of our previously developed… Expand
Planar Chirality of Imidazole-Containing Macrocycles - Understanding and Tuning Atropisomerism
The synthesis and characterization of imidazole-containing macrocycles displaying planar chirality has been achieved. HLPC and NMR studies revealed the crucial role of the alicyclic chain length in… Expand
The Synthesis of Two Regioisomeric Aldehydes with a Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent-Free Intramolecular 1,3-Dipolar Cycloaddition Reactions
The paper describes the synthesis of two regioisomeric 2-amino-3-formyl- and 3-amino-2-formyl-substituted derivatives of tetrahydrobenzo[ b ]thiophene and their subsequent thermally initiated… Expand
Comprendre les réactions pour mieux les développer et les utiliser
Development of a Regioselective N‐Methylation of (Benz)imidazoles Providing the More Sterically Hindered Isomer.
Development of a general and regioselective N-alkylation strategy of azoles and synthesis of original imidazole derivatives of chemical and biological interest
- E. V. D. Berge
Imidazoles are key structures in medicinal chemistry. Numbers of imidazole derivatives have found applications in the treatment of infectious diseases, cancer, metabolic, cardiovascular, and CNS… Expand
The Synthesis of Two Regioisomeric Aldehydes with a Tetrahydrobenzo[b]thiophene Scaffold and Their Application in Solvent‐Free Intramolecular 1,3‐Dipolar Cycloaddition Reactions.
Microwave initiated intramolecular cyclizations of in situformedazomethine ylide with allylamino group at substitutedthiophene
Synthesis of new pyrrolo[3,2-c]pyridine heterocycles by microwave induced cycloaddition reaction. The reaction is proceeding in two subsequent steps. The first is intermolecular reaction of secondary… Expand