Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.

• Delphine Benarroch-Popivker, Sabrina Pisano, +19 authors Marie-Josèphe Giraud-Panis
• Molecular cell
• 2016

The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps ∼ 90 bp of DNA… (More)

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.

• Michaël Cerezo, Abdelali Lehraiki, +27 authors Stéphane Rocchi
• Cancer cell
• 2016

We have discovered and developed a series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma cells tested,… (More)

Metformin: Focus on Melanoma

• Emilie Jaune, Stéphane Rocchi
• Front. Endocrinol.
• 2018

Metformin is the most common biguanide used in the treatment of diabetes, with 120 million treated patients worldwide. Metformin decreases hyperglycemia without inducing hypoglycemia in diabetic… (More)

Discovery and Optimization of N-(4-(3-Aminophenyl)thiazol-2-yl)acetamide as a Novel Scaffold Active against Sensitive and Resistant Cancer Cells.

• Antoine Millet, Magali Plaisant, +6 authors Rachid Benhida
• Journal of medicinal chemistry
• 2016

Cancer is the second cause of deaths worldwide and is forecasted to affect more that 22 million people in 2020. Despite dramatic improvement in its care over the last two decades, the treatment of… (More)

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.

• Michaël Cerezo, Abdelali Lehraiki, +27 authors Stéphane Rocchi
• Cancer cell
• 2016

Graphical Abstract Highlights d HA15 is a molecule that targets specifically BiP/GRP78/ HSPA5 d HA15 induces ER stress leading to cancer cell death in vitro and in vivo d HA15 overcomes BRAF… (More)

Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells

• Najla El-Hachem, Nadia Habel, +11 authors R obert Ballotti
• Cell Death & Differentiation
• 2018

HACE1 is an E3 ubiquitin ligase described as a tumour suppressor because HACE1-knockout mice develop multi-organ, late-onset cancers and because HACE1 expression is lost in several neoplasms, such as… (More)

PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness.

• Lisa Kaminski, Stéphanie Torrino, +16 authors Frédéric Bost
• 2019

Although tumorigenesis is dependent on the reprogramming of cellular metabolism, the metabolic pathways engaged in the formation of metastases remain largely unknown. The transcriptional co-activator… (More)

• ‹
• 1
• ›