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Metformin: Focus on Melanoma
TLDR
The novel data demonstrate the importance of developing metformin and new biguanide-derived compounds as potential treatments against a number of different cancers, particularly melanoma.
Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells
TLDR
It is demonstrated that HACE1 promoted melanoma cell migration and adhesion in vitro and was required for mouse lung colonisation by melanoma cells in vivo and a novel molecular cascade involved in the regulation of fibronectin secretion, integrin expression and melanomacell adhesion is disclosed.
Discovery and Optimization of N-(4-(3-Aminophenyl)thiazol-2-yl)acetamide as a Novel Scaffold Active against Sensitive and Resistant Cancer Cells.
TLDR
Lead compound 6b leads to cell death by concomitant induction of apoptosis and autophagy, shows good pharmacokinetic properties, and demonstrates a significant reduction of tumor growth in vivo on A375 xenograft model in mice.
PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness.
TLDR
Downregulation of PGC-1α renders PCa cells dependent on polyamine to promote metastasis, and analysis of in vivo metastases and clinical data from prostate cancer patients support the proposition that the P GC-1 α/c-MYC/ODC1 axis regulates polyamine biosynthesis and prostate cancer aggressiveness.
Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma
TLDR
The mechanism of action of HA344 provides potential therapeutic avenues for patients with CMM and a broad range of different cancers, and acts synergistically with BRAF inhibitors on CMM cell lines in vitro.
Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies
TLDR
The strong efficacy of CRO15 to reduce the growth of melanoma xenograft sensitive or resistant to BRAF inhibitors opens interesting perspective.