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TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.
The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps ∼ 90 bp of DNAExpand
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Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
We have discovered and developed a series of molecules (thiazole benzenesulfonamides). HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma cells tested,Expand
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Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance.
Graphical Abstract Highlights d HA15 is a molecule that targets specifically BiP/GRP78/ HSPA5 d HA15 induces ER stress leading to cancer cell death in vitro and in vivo d HA15 overcomes BRAFExpand
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Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells
HACE1 is an E3 ubiquitin ligase described as a tumour suppressor because HACE1-knockout mice develop multi-organ, late-onset cancers and because HACE1 expression is lost in several neoplasms, such asExpand
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Discovery and Optimization of N-(4-(3-Aminophenyl)thiazol-2-yl)acetamide as a Novel Scaffold Active against Sensitive and Resistant Cancer Cells.
Cancer is the second cause of deaths worldwide and is forecasted to affect more that 22 million people in 2020. Despite dramatic improvement in its care over the last two decades, the treatment ofExpand
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Metformin: Focus on Melanoma
Metformin is the most common biguanide used in the treatment of diabetes, with 120 million treated patients worldwide. Metformin decreases hyperglycemia without inducing hypoglycemia in diabeticExpand
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PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness.
Although tumorigenesis is dependent on the reprogramming of cellular metabolism, the metabolic pathways engaged in the formation of metastases remain largely unknown. The transcriptional co-activatorExpand
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Développement préclinique d’un nouveau composé anti-mélanome : activation des voies AMPK et p53 pour induire la mort des cellules de mélanome
200 000 nouveaux cas de melanome et 65 000 deces sont dus a ce cancer de la peau chaque annee. Le melanome represente donc un veritable probleme de sante publique. Actuellement, plus de 50 % desExpand