Emilie Heckel

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In vertebrates, heart pumping is required for cardiac morphogenesis and altering myocardial contractility leads to abnormal intracardiac flow forces and valve defects. Among the different mechanical cues generated in the developing heart, oscillatory flow has been proposed to be an essential factor in instructing endocardial cell fate toward valvulogenesis(More)
Heterozygous mutations in dynamin 2 (DNM2) have been linked to dominant Charcot-Marie-Tooth neuropathy and centronuclear myopathy. We report the first homozygous mutation in the DNM2 protein p.Phe379Val, in three consanguineous patients with a lethal congenital syndrome associating akinesia, joint contractures, hypotonia, skeletal abnormalities, and brain(More)
b reanung ei,nes l~isehgmses zu schaffen, wodurch alle bisher n i t Kohle beheizten Zimmerumd Kochdfen darch Gasherde ersetzt werden kdnnten, d~hnlich Hegen die Verh~ltni~se in .den industr iet len Be~rieben. Nieht fiberall werden s ich die M i t te l fltissig n~chen ~assen, urn von der Kohlenfeuerung un te r d e n Dampfkes~el zur Beheizung desselben n i t(More)
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