Emiliano Zamponi

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Mitochondrial networks have been shown to exhibit a variety of complex behaviors, including cell-wide oscillations of mito-chondrial energy states, as well as a phase transition in response to oxidative stress. Since functional status and structural properties are often intertwined, in this work we look at the structural properties of the organelle in(More)
Our understanding of protein and lipid trafficking in eukaryotic cells has been challenged by the finding of different forms of compartmentalization and cargo processing in protozoan parasites. Here, we show that, in the absence of a Golgi compartment in Giardia, proteins destined for secretion are directly sorted and packaged at specialized ER regions(More)
Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their influence on cocaine-dependent behavioral and neuronal plasticity has not been explained. In this study, we employed a knockout (KO) model(More)
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