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The activity of single cells was recorded in behaving monkeys while they performed several eye-hand directional motor tasks. The results revealed that in parietal area 7a there exists a directional representation of eye and hand motor space that, contrary to that of superior parietal, premotor and motor cortex, is highly skewed toward the contralateral(More)
The elevated plus-maze test (PM) and open-field test (OF) are routinely used to study anxiety-related behaviour in mouse. However, the data obtained with these tests have often been contradictory, probably because of differences between laboratories in the selection and analysis of behavioural parameters. We have characterised the pattern of mouse anxiety(More)
The ability of sensory-motor circuits to integrate sensory evidence over time is thought to underlie the process of decision-making in perceptual discrimination. Recent work has suggested that the NMDA receptor contributes to mediating neural activity integration. To test this hypothesis, we trained three female rhesus monkeys (Macaca mulatta) to perform a(More)
Neural activity was recorded in area PE (dorsorostral part of Brodmann's area 5) of the posterior parietal cortex while monkeys performed arm reaching toward memorized targets located at different distances from the body. For any given distance, arm movements were performed while the animal kept binocular eye fixation constant. Under these conditions, the(More)
Primates explore their visual environment by redirecting the gaze to objects of interest by alternating eye movements and periods of steady fixation. During this task, the fixation point changes frequently in depth. Therefore, the representation of object location based on retinal disparity requires frequent updating. Neural activity was recorded in the(More)
In the study of decision making, emphasis is placed on different forms of perceptual integration, while the influence of other factors, such as memory, is ignored. In addition, it is believed that the information underlying decision making is carried in the rate of the neuronal response, while its variability is considered unspecific. Here we studied the(More)
In a previous study on anxiety-related behaviours of the genetically and behaviourally distant inbred mouse strains C57BL/6 and BALB/c using the Elevated plus-maze (EPM) and Open-field (OF) apparatuses, we identified a number of variables, the factorial scores of which were grouped by principal component analysis (PCA) into factors specifically describing(More)
We used the behavioral task and theoretical construct of the countermanding paradigm to test whether there is any difference between the inhibitory control of the finger, wrist, and arm. Participants were instructed (primary task) to respond to a directional go signal presented at the fovea by pressing a button with either their index or middle fingers,(More)
Anxiety is an important modulator of social behavior across species and parallel defects in anxiety and social interaction are frequently observed in mental illnesses such as autism and schizophrenia. The mouse is a powerful model organism to study the molecular genetic basis of these behaviors. Here we analyzed the relationship between social behavior and(More)
Inhibition of inappropriate responses allows to shape the motor behavior accordingly to the context in which a subject acts and is an essential executive function. Inhibition has been poorly investigated in Down Syndrome (DS) patients. We tested, using a countermanding task, the inhibitory control in a group of DS patients and in a group of patients with(More)