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BACKGROUND Ectopic production of adrenocorticotropic hormone (ACTH) by neuroendocrine tumours (NET) is a rare condition, occult presentations often hampering the diagnosis. Although NET are relatively frequent in the ileon and Meckel diverticulum, we describe the first Cushing's syndrome due to ectopic adrenocorticotropic syndrome (CS-EAS) arising from a(More)
Gel chromatography in columns with Sephadex G-50 and biogel P-2 was used to separate a number of fractions formed in k-casein of cow's milk after short-term treatment with swine trypsin. These fractions, similar to beta-casomorphin, are capable of reducing the respiration and heart rates in rabbits after intravenous injection in a dose of 100 micrograms/kg,(More)
Low molecular peptide fragment [molecular weight 700-2,000] was isolated from the preparation of k-caseine glycomacropeptide using gel chromotography on Sephadex G-25 superfine. After intravenous administration the peptide inhibited gastric secretion more distinctly as compared with the initial preparation. The data obtained suggest that the inhibitory(More)
Relationship between the type of protein digestion in gastrointestinal tract and coefficient of protein efficiency (CPE) was studied after artificial feeding of 15-21 days-old rats using milk substitutes. Distinctly low level of CPE was observed after rapid transfer of blood serum albumin (BSA) along the gastrointestinal tract accompanied by the protein(More)
Starting from 15 days of age the rats were transferred to formula feeding with liquid diet adapted to the rat milk composition in terms of the main parameters. It was shown that caseine exclusion from the rat diet during the early postnatal period of the development and its replacement by proteins of milk serum or by bovine serum albumin that are not(More)
Caseinophosphopeptides (CPPs) are phosphorylated casein-derived peptides which possess the ability to bind and solubilise minerals, such as Ca2+. The high bioavailability of Ca2+ fram milk and dairy products has been attributed to the production of CPPs which are produced following digestion of casein by the action of gastrointestinal proteinases. CPPs,(More)
Glycomacropeptide, which provoked a significant inhibition of food motility of the stomach fundus on intravenous injection to dogs in a dose of 10 mg, was isolated from the products of restricted pepsin proteolysis of cow kappa-casein with the aid of gel chromatography on Sephadex G-25 and G-10. Glycomacropeptide administered on an empty stomach produced(More)