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Biological responses to estrogens in normal and malignant tissues are mainly mediated by the estrogen receptors ERα and ERβ, which function as ligand-activated transcription factors. In addition, the G protein-coupled receptor GPR30 (GPER) mediates estrogenic signaling in breast cancer cells and cancer-associated fibroblasts (CAF) that contribute to cancer(More)
Obesity is a chronic and multifactorial disorder that is reaching epidemic proportions. It is characterized by an enlarged mass of adipose tissue caused by a combination of size increase of preexisting adipocytes (hypertrophy) and de novo adipocyte differentiation (hyperplasia). Obesity is related to many metabolic disorders like hypertension, type 2(More)
Biological responses to estrogens in normal and malignant tissues are mainly mediated by the estrogen receptors ERa and ERb, which function as ligand-activated transcription factors. In addition, the G protein– coupled receptor GPR30 (GPER) mediates estrogenic signaling in breast cancer cells and cancer-associated fibroblasts (CAF) that contribute to cancer(More)
Pr ecis: These findings demonstrate the importance of commensal bacteria in supporting the host immune response against cancer in mucosal tissues and also suggest deleterious effects of antibiotic treatment on cancer susceptibility and progression. Pr ecis: This study offers a preclinical rationale for coadministering immune checkpoint therapies with cancer(More)
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