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The advent of phylogenetic DNA microarrays and high-throughput pyrosequencing technologies has dramatically increased the resolution and accuracy of detection of distinct microbial lineages in mixed microbial assemblages. Despite an expanding array of approaches for detecting microbes in a given sample, rapid and robust means of assessing the differential(More)
Rab monomeric GTPases regulate specific aspects of vesicle transport in eukaryotes including coat recruitment, uncoating, fission, motility, target selection and fusion. Moreover, individual Rab proteins function at specific sites within the cell, for example the ER, golgi and early endosome. Importantly, the localization and function of individual Rab(More)
Previous studies from our institution have shown that serum secretory phospholipase A 2 (sPLA 2) levels are markedly increased in sickle cell disease (SCD) patients with acute chest syndrome (ACS) 1 and that sequential measurements of sPLA 2 are useful in predicting the subsequent development of ACS in patients hospitalized for vasoocclusive crisis (VOC). 2(More)
Universal and species-specific quantitative polymerase chain reaction-based methods were employed to compare the effectiveness of four distinct materials used to collect biological samples from metal surfaces. Known cell densities of a model microbial community (MMC) were deposited onto metal surfaces and subsequently collected with cotton and nylon-flocked(More)
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