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Estimating glomerular filtration rate (GFR) in children. The average between a cystatin C- and a creatinine-based equation improves estimation of GFR in both children and adults and enables
Abstract Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFRcystatin C) and a creatinine-based (eGFRcreatinine) equation shows atExpand
Endogenous markers for kidney function in children: a review
An in-depth review of the physiology, measurement and clinical use of creatinine, urea, cystatin C, beta-trace protein, and beta-2 microglobulin in children and the generation of eGFR equations in children is addressed. Expand
Accurate eGFR reporting for children without anthropometric data.
Combining the height-independent FASage and SchwartzCys equations substantially improves accuracy and performs comparably to height-dependent equations, which allows laboratories to directly report eGFR in children. Expand
Estimation of GFR in children using rescaled beta-trace protein.
Rescaled BTP concentrations are a simple method for estimating GFR in children and the additional value of BTP for the estimation of GFR compared to rescaled creatinine and cystatin C still remains to be demonstrated. Expand
Combining GFR estimates from cystatin C and creatinine—what is the optimal mix?
In the absence of height data, the optimal strategy for estimating GFR in children is by using the geometric mean of FASage and FAScys, and when there is large disagreement between the two, weighted means based on diagnosis improve accuracy. Expand
Evidence for shrunken pore syndrome in children
A definition based on eGFRcys/eGFRcrea/exogenous clearance study may be useful to study the effect of SPS on creatinine metabolism, suggesting glomerular pore size as a common denominator. Expand
Concordance between creatinine- and cystatin C-based eGFR in clinical practice
In a broad pediatric nephrological population, |ΔeGFR| is below 40% in the vast majority of measurements, and the mean of eGFRcrea and eG FRcys can be used as an accurate estimate of GFR. Expand