Emil Wirostko

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Ultrastructurally unique and distinctive non-cultivable human and mouse uveitis and vitritis producing bacteria (B) that parasitise, differentiate into both cell walled and cell wall deficient variants within, and destroy polymorphonuclear leucocytes (PMNL) were recently reported to be commonly present in the vitreous of chronic idiopathic vitritis(More)
In chronic idiopathic vitritis (CIV) corticosteroid treatment failures, vitrectomy is beneficial. Searching for vitreous microbial agents, 14 vitrectomy specimens from 11 corticosteroid-failing CIV patients were inoculated into numerous in vitro cultural systems; Gram's-, Giemsa-, periodic acid-Schiff- (PAS), and Dieterle-stained centrifuged sediment smears(More)
Vitreous humour from chronic idiopathic vitritis (CIV) patients containing 0.5-0.7 micron diameter bacteria-like bodies (BLB) in polymorphonuclear leucocytes was inoculated into the eyelids of 100 mice. 200 control mice received either eye-bank vitreous or saline. After 12 months, 53 mice that received CIV vitreous, but none of the controls, had clinical(More)
Vitritis, the presence of leucocytes in the acellular ocular vitreous, often accompanies ocular vasculitis (V). Non-cultivatable intracellular mollicutes (M), i.e. cell wall deficient bacteria, readily identified by transmission electron microscopy (TEM), are well known plant vascular pathogens. Recently similar intracellular polymorphonuclear leucocytes(More)
Uveitis is inflammation of the ocular vascular coats. Most uveitis is chronic, idiopathic, and considered to have an endogenous, possibly autoimmune pathogenesis. Chronic idiopathic uveitis occurs in isolation or with various systemic diseases including inflammatory bowel diseases. Using a transmission electron microscope vitreous leucocyte parasitizing and(More)
Patients with juvenile rheumatoid arthritis (JRA) commonly develop serious eye disease, particularly chronic uveitis. Most chronic uveitis is idiopathic. Mollicute-like organisms (MLO) were recently reported to be a common cause of chronic uveitis. MLO are pathogenic intracellular cell wall deficient bacteria. No culture system exists for MLO. Disease(More)
Mollicute-Like Organisms (MLO) have been reported to be a cause of uveal tract and orbital chronic inflammatory disease. MLO are intracellular cytopathogenic cell wall deficient bacteria. No culture system exists for MLO, MLO disease diagnosis is based chiefly on direct detection of the organisms within diseased cells using a transmission electron(More)
Idiopathic Uveitis (IU) may occur as either an isolated ocular disease or with other systemic diseases such as Crohn's Disease (CD). As many as 33% of CD patients demonstrate IU, and frequently their gut and IU course and severity are similar. Rifampin produces remissions of isolated IU, and Rifampin has been used to treat gut CD with varying success. In(More)