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Journals and Conferences
Experiments were performed to determine the cause of "acid crash", a phenomenon which occasionally occurs in pH-uncontrolled batch fermentations resulting in premature cessation of ABE (acetone butanol) production. The results indicate that "acid crash" occurs when the concentration of undissociated acids in the broth exceeds 57 - 60 mmol/l. Prevention can… (More)
By X-irradiation ofM/M + embryos and larvae to induce mitotic recombination, clones ofM +/M+ genotype were obtained (Fig. 1). Since such cells grow faster than the surroundingM/M +-cells they can fill large areas within the compartments of an imaginal disc. The present studies concentrated mainly on the three leg discs. Clones were induced by doses of 1000… (More)
The decrease of the tryptophan fluorescence (Ex/Em = 282/331 nm) was used to monitor the kinetics of copper-mediated LDL oxidation. Cu2+ causes a concentration-dependent quenching of the LDL Trp-fluorescence, the maximum of about 22% suggests that 8-9 Trp residues (out of a total of 37) are accessible for Cu2+ ions. Decomposition of LDL tryptophan commences… (More)
Human hepatoma cells (HepG2) were exposed to several heavy metal salts and the induction of heat shock protein 70 (hsp70) mRNA was analysed by the reverse transcriptase-polymerase chain reaction (RT-PCR). Metals were added to the cell medium at concentrations ranging from 0.1 to 100 microM and incubation was continued for 4 h. In addition we analysed the… (More)
The transdetermination capacities of leg discs ofDrosophila melanogaster were examined by mechanically disrupting and kneading whole discs from late third instar larvae and by culturing the resulting tissue mass for 10–14 days in adult female abdomens where the cells continued to divide. The grown implants were then dissected from the abdomens and injected… (More)
When chronically administered, 3-hydroxymethyl N-methyl piperidine (4-chlorophenoxy) acetate, hydrochloride, causes reduced food intake and weight gain in obese (fa/fa) rats. We observe an increase in free fatty acid concentration of obese (fa/fa) rats treated for 12 days.
The synthesis of some selected PAF-acether homologues with an alkoxy-chain length from C1 to C20 in position 1 is described. All agonist activities are closely correlated among themselves and with the calculated fatty-chain hydrophobicity. After a discussion on recent published results and comparison with our data, we conclude that the ether oxide function… (More)
Adding 3-hydroxymethyl N-methyl piperidine (4-chlorophenoxy) acetate, A, at increasing doses in the incubation medium leads to an increase in glycerol release from white adipocytes or brown adipose tissue. This stimulation is dose-dependent and optimal with 10(-6) M.
In order to undertake a quantitative assessment of the contribution of the hydrophobic effect of the etheroxid chain to agonistic activity, it was necessary to include in the calculated data a highly lipophilic platelet-activating factor (PAF) analogue. The synthesis of such a compound--racemic 1-O-docosyl-2-O-acetylglycero-3-phosphocholine (C22 PAF)--is… (More)