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In the endocrine pancreas, chromogranin-A and pancreastatin have been suggested to inhibit islet insulin secretion, whereas chromogranin-B has not been studied in this context. Furthermore, a putative effect by chromogranins on IAPP secretion is unknown. We aimed to elucidate the endogenous effect of chromogranin-A, pancreastatin and chromogranin-B on islet(More)
Human erythrocyte acetylcholinesterase (AChE) solubilized with Triton X-100 and obtained as a complex with micelles containing Triton and membrane phospholipids was incubated with immunoglobulins (Igs) from patients with amyotrophic lateral sclerosis (ALS) and from normal individuals. The temperature dependence of the AChE activity was determined. Biphasic(More)
The problem of estimating mean and covariances of a multivariate normal distributed random vector has been studied in many forms. This thesis focuses on the estimators proposed in [15] for a banded covariance structure with m-dependence. It presents the previous results of the estimator and rewrites the estimator when m = 1, thus making it easier to(More)
The field of statistics is becoming increasingly more important as the amount of data in the world grows. This thesis studies the Growth Curve model in multivariate statistics which is a model that is not widely used. One difference compared with the linear model is that the Maximum Likelihood Estimators are more complicated. That makes it more difficult to(More)
Immunoglobulin (Ig)-mediated activity in plasma directed towards normal blood type matched red blood cells (RBC) inducing haemolysis in vitro has earlier been demonstrated to be a characteristic feature in ALS-patients. In this study, saliva of ALS-patients, normal and diseased controls was tested with the same in vitro test. An increased degree of(More)
The problem of estimating mean and covariances of a mul-tivariate normally distributed random vector has been studied in many forms. This paper focuses on the estimators proposed by Ohlson et al. (2011) for a banded covariance structure with m-dependence. We rewrite the estimator when m = 1, which makes it easier to analyze. This leads to an adjustment, and(More)
The secretion of islet amyloid polypeptide (IAPP) during the course of insulin-dependent diabetes mellitus (IDDM) is essentially unknown. In the present study we elucidated this issue by examining IAPP and insulin secretion from isolated pancreatic islets obtained from IDDM-prone female NOD mice aged 6-9 weeks and 12-15 weeks and from non-IDDM-prone male(More)
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