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To investigate the modulatory effects of sigma ligands on the N-methyl-D-aspartate (NMDA) receptor-ion channel complex in vivo, we examined the intact cell binding of 3H-N-[1-(2-thienyl)cyclohexyl]piperidine (3H-TCP) to cultured neuronal cells prepared from fetal rat telencephalon. The 3H-TCP binding was saturable, reversible, and inhibited by a selective(More)
Remarkable changes in personality, emotion and behavior were observed in a 66-year-old female with bilateral infarction of the medial inferior portion at the temporo-occipital region. Aggressiveness, emotional lability and indifference were noted in the patient as psychiatric manifestation. No definite delirium, however, was observed. A neuroradiological(More)
This paper presents a method for designing, compiling and annotating corpora intended for language learners. In particular, we focus on spoken corpora for being used as complementary material in the classroom as well as in examinations. We describe the three corpora (Spanish, Chinese and Japanese) compiled by the Laboratorio de Lingüística Informática at(More)
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