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Rho kinase (ROCK) is involved in various physiological functions, including cell motility, vasoconstriction, and neurite extension. Although a functional role of ROCK in nociception in the central… (More)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are now understood to fall into one of two agent classes in clinical use. Traditional NSAIDs inhibit both cyclooxygenases-1 and 2 (COX-1, 2), which act… (More)
Background RANK/RANKL signaling is the pathway of osteoclast differentiation and activation. In many bone diseases, the balance of bone formation and bone resorption is impaired. In osteoporosis,… (More)