Emanuele Nicastro

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The intestinal mucosa is an important target of human immunodeficiency virus (HIV) infection. HIV virus induces CD4+ T cell loss and epithelial damage which results in increased intestinal permeability. The mechanisms involved in nutrient malabsorption and alterations of intestinal mucosal architecture are unknown. We previously demonstrated that HIV-1(More)
Islet and hepatocyte transplantation are associated with tissue factor-dependent activation of coagulation which elicits instant blood mediated inflammatory reaction, thereby contributing to a low rate of engraftment. The aim of this study was i) to evaluate the procoagulant activity of human adult liver-derived mesenchymal progenitor cells (hALPCs), ii) to(More)
OBJECTIVE E-learning is a candidate tool for clinical practice guidelines (CPG) implementation due to its versatility, universal access and low costs. We aimed to assess the impact of a five-module e-learning course about CPG for acute gastroenteritis (AGE) on physicians' knowledge and clinical practice. STUDY DESIGN This work was conceived as a pre/post(More)
Clinical practice guidelines (CPGs) are systematically developed documents that assist healthcare practitioners in making decisions about appropriate care for specific diseases based on evidence. In this context, acute gastroenteritis (AGE) in pediatrics is a suitable model for guidelines implementation and CPGs are available and very straightforward.(More)
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