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The ALS Functional Rating Scale (ALSFRS) is a validated rating instrument for monitoring the progression of disability in patients with amyotrophic lateral sclerosis (ALS). One weakness of the ALSFRS as originally designed was that it granted disproportionate weighting to limb and bulbar, as compared to respiratory, dysfunction. We have now validated a(More)
BACKGROUND Brain derived neurotrophic factor (BDNF) is a potent survival factor for motoneurons. This study investigated the safety and tolerability of recombinant methionyl human BDNF (r-metHuBDNF) infused intrathecally by means of an implanted pump in patients with ALS. METHODS Twenty-five patients with probable or definite ALS were treated with either(More)
These are but a few of the controversies and pressures facing Sponsors of clinical trials in ALS. All researchers in the area share the hope that the current level of interest in clinical trials in ALS will lead to the development of effective therapies for this disease. It should be recognized that the long-term goal of all groups involved in ALS trials is(More)
Cardiac surgery in patients with preexisting bleeding disorders can be a challenge. Cardiopulmonary bypass can lead to bleeding disorders, above all in patients with coagulopathy. We report the case of a 42-year-old woman, with type I von Willebrand disease, who underwent off-pump coronary artery bypass grafting. Beating heart surgery associated with an(More)
We report a case of malfunction of a sheetless intra-aortic balloon pump due to rupture of the internal metal wire rather than the plastic balloon itself. In fact, the balloon envelope remained intact up to the extraction, keeping the two parts of the broken catheter together, avoiding more serious complications (Fig. 1). Figure 1: Intra-aortic balloon pump(More)
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