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  • Franz G. Bauernfeind, Gábor Horváth, +9 authors Eicke Latz
  • Biology, Medicine
  • Journal of immunology
  • 2009 (First Publication: 15 July 2009)
  • The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels. Pattern recognition and cytokine receptors control pro-IL-1beta transcription whereas inflammasomes regulateContinue Reading
  • Teresa Fernandes-Alnemri, J Wu, +6 authors Emad S. Alnemri
  • Medicine, Biology
  • Cell Death and Differentiation
  • 2007 (First Publication: 1 September 2007)
  • Pyroptosis is a caspase-1-dependent inflammatory form of cell death. The adapter protein ASC binds directly to caspase-1 and is critical for caspase-1 activation in response to a broad range ofContinue Reading
  • Jun Liang Wang, Danmei Liu, +6 authors Zhishan Huang
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Publication: 20 June 2000)
  • Bcl-2 and related proteins are key regulators of apoptosis or programmed cell death implicated in human disease including cancer. We recently showed that cell-permeable Bcl-2 binding peptides couldContinue Reading
  • Ramesh S. Hegde, Srinivasa M Srinivasula, +8 authors Emad S. Alnemri
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2002 (First Publication: 4 January 2002)
  • To identify human proteins that bind to the Smac and caspase-9 binding pocket on the baculoviral inhibitor of apoptosis protein (IAP) repeat 3 (BIR3) domain of human XIAP, we used BIR3 as an affinityContinue Reading