Elzbieta Maria Przedpelska-Ober

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Although Alzheimer's disease (AD) is a primary degenerative disorder, a microglial-mediated inflammatory response, provoked by amyloid beta (Abeta), contributes to the neurodegeneration and subsequently to the cell loss. Since such an inflammatory contribution to neurodegeneration may influence disease progression, a basic question arises concerning the(More)
PURPOSE The purpose of the study was to determine the frequency of occurrence of polymorphisms of genes MTHFR (C677T), MTR (A2756G), and MTHFD1 (G1958A), as well as to analyze the concentration of homocysteine (Hcy), methionine (Met), asymmetric dimethylarginine (ADMA), and arginine (Arg) in epileptics treatment with antiepileptic drugs (AEDs), and(More)
BACKGROUND Recent data have shown that in the early stages of Alzheimer's disease (AD), vascular brain lesions might promote the progression of cognitive decline or might even precede neuronal damage. METHODS Ischemic brain lesions, recognized on computed tomography or magnetic resonance imaging, were analyzed retrospectively in 72 patients with early and(More)
Parkison's disease causes damage to the central nervous system resulting in bradykinesia, muscle rigidity, rest tremor and dysarthric speech. In clinical terms dysarthria denotes the dysfunction of articulation, phonation and respiration. It is brought about by the impairment of neural paths innervating the speech apparatus, thus causing a decreased ability(More)
Investigations were performed on the gastrocnemius muscle in 27 human fetuses aged 9-32 weeks, 2 fetuses of 74 and 220 C.-R. length were examined electron microscopically. The first muscle spindles were observed at 11 and 12 weeks and were covered by a capsule composed of single layer of cells. The intrafusal fibers, being in myotube stage, contained well(More)
The new electromyographic test is based on fast Fourier transformation application for analysis of global electromyograms. Specifically designed Dynalog apparatus is described. Dynalog records EMG signal and transfers it to IBM-PC. One hundred thirty-eight global electromyograms were taken from 4 muscle groups (m.rectus femoris, m.deltoideus, mm. flexores(More)
This study deals with mathematical assessment of physiologic and pathologic EMG frequency distribution by means of ranging. Material consisted of 161 pathologic EMG (63 myogenic cases, 98 neurogenic cases). In physiologic EMG power density distribution shows the highest values between 50 and 100 Hz, the lowest between 200 and 250 Hz. From 0 to 50 Hz power(More)
The author reviews two decades of clinical research directed towards the links between disturbances of the oculomotor functions and the severity and progress of Alzheimer's disease. Two basically different streams of research are identified. The first based on precise, quantitative examination of automatic or reflexive eye movements, including saccadic(More)
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