Elwira Smolińska

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Flavonoids have been studied as potential agents in medicine for many years. Among them, genistein was found to be active in various biological systems, mainly in prevention of cancer. Our recent work supported the idea that genistein also impacts multiple cellular processes in healthy fibroblasts; however, its effects on cell cycle-related pathways(More)
Flavonoids were found previously to modulate efficiency of synthesis of glycosaminoglycans (GAGs), compounds which are accumulated in cells of patients suffering from mucopolysaccharidoses (MPSs). The aim of this work was to determine effects of different flavonoids (genistein, kaempferol, daidzein) used alone or in combinations, on expression of genes(More)
Natural flavonoids such as genistein, kaempferol and daidzein were previously found to be able to reduce efficiency of glycosaminoglycan synthesis in cells of patients suffering from mucopolysaccharidoses, inherited metabolic diseases with often brain disease symptoms. This feature was employed to test these compounds as potential drugs for treatment other(More)
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Thirty six patients with Hirschsprung's disease were treated with a Duhamel pull-through procedure. Of the patients 32 were boys, 31 were diagnosed in the first three months of life, 30 had aganglionosis restricted to the rectum and to the sigmoid colon. The absence of mortality and the low complication rate confirmed that the Duhamel operation is a benign(More)
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