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30 Hyperthermophilic microorganisms, which form closed, resistant to various physical and chemical environmental factors, communities of deep hot springs, are a unique object of study of mechanisms of adaptation and stress tolerance. Complete sequencing and annotation of their genomes allow to study extremozyme and the mechanisms of protein adaptaa tion at(More)
The effects of heating on the structure and stability of multimeric TET aminopeptidase (APDkam589) were studied by differential scanning calorimetry, tryptophan fluorescence quenching, and dynamic light scattering. Thermally induced structural changes in APDkam589 were found to occur in two phases: local conformational changes, which occur below 70 °C and(More)
A gene encoding superoxide dismutase was revealed in the genome of the thermoacidophilic crenarchaeon Acidilobus saccharovorans. A recombinant expression vector was constructed and transformed into E. coli cells. The novel recombinant superoxide dismutase was purified and characterized. The enzyme was shown to be an iron-dependent super-oxide dismutase able(More)
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