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PURPOSE Although cytogenetic aberrations at 10q have been reported in up to 27% of uveal melanomas, the role of PTEN in the pathogenesis of uveal melanoma is largely unknown. Our aim was to determine the frequency and clinical significance of PTEN alterations in uveal melanomas. PATIENTS AND METHODS We examined PTEN expression using immunohistochemistry(More)
Drugs that block norepinephrine reuptake offer promise as opioid potentiators, because norepinephrine mediates opioid analgesia but not side effects such as sedation or nausea. In a two-by-two factorial design, we randomized 62 inpatients with pain following major surgery to receive either desipramine, 50 mg by mouth, or placebo at 6 a.m. on the first day(More)
Nucleoside triphosphatase (NTPase) activity was demonstrated at the submicroscopic level in the frog retina by the Wachstein-Meisel method utilizing various purine and pyrimidine nucleosides. Under the electron microscope magnesium-activated NTPase was localized in the outer and inner segments, and in the plexiform layers. NTPase active sites in the cones(More)
BACKGROUND Laparoscopic dismembered pyeloplasty has become the "gold-standard" procedure for pelviureteric junction (PUJ) obstruction but consists of a steep learning curve especially via the retroperitoneal route. AIMS To examine the feasibility and safety of introducing this technique via the retroperitoneal approach to a laparoscopic naïve center. (More)
PURPOSE Overexpression of vascular endothelial growth factor (VEGF) and overrepresentation of the 6p region have been reported with a wide variation in uveal melanoma. The aim of the current study is to identify the frequency of copy number alteration in the 6p21 region and its correlation with the expression of VEGF in uveal melanoma. EXPERIMENTAL DESIGN(More)
PURPOSE To describe whether a technique of treatment of a combined acanthamoeba-stenotrophomonas keratitis with a conjunctival flap followed by a penetrating keratoplasty is successful. METHODS A case of chronic ring-shaped keratitis in which Stenotrophomonas maltophilia was isolated with corneal scrapings, and acanthamoeba cysts were found with a corneal(More)
E p o x y resins h a v e been established as desirable e m b e d d i n g m e d i a for electron m i c r o s c o p y (1-5). Finck (6) described a n epoxy resin, E P O N 812 (Shell) t , w h i c h in a d d i t i o n to its other desirable characteristics, is also a p p r e c i a b l y miscible with water. H e noted t h a t p r o l o n g e d alcohol d e h y d r(More)
PURPOSE To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine. METHODS A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due to incapacitating pain. RESULTS The eye showed(More)
Red blood cell proton relaxation times T1 and T2 were measured in samples from chronic alcoholic patients abstinent for varying periods from 1 week to over 6 months. T1 and T2 were elevated in the early stages of abstinence and declined to the values of controls after 8 weeks. Changes in the water content of the red blood cells and the mean corpuscular(More)