Elsabè Powell

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With probably fewer than 3000 individuals alive in the biodiversity hotspot of the Succulent Karoo in southern Africa, populations of the endemic, Giant Quiver Tree, Aloe pillansii, are thought to be declining and thus threatened with extinction. Using repeat photography and field data we investigated the long-term changes in one population of A. pillansii(More)
We infused peripheral blood stem cells (PBSC) into 51 patients with various malignant disorders, after myeloablative conditioning. Twenty-four patients also received autologous bone marrow (PBSC + BM). In a multivariate analysis, the only statistically significant predictors of neutrophil engraftment were log-dose CFU-GM (P < 0.001) and the number of prior(More)
Mechanical properties of the lung were studied in nine healthy lowlanders during a 6-day sojourn at an altitude of 3,457 m. In comparison to sea-level values, it was found at altitude that 1) lung volumes measured by plethysmography including total lung capacity, vital capacity, and functional residual capacity (FRC) presented small changes not exceeding(More)
To examine the mechanism of hyperinflation in bronchial asthma we studied lung and chest wall mechanics in 7 asymptomatic patients in whom progressive bronchoconstriction was induced by doubling the amount of inhaled aerosolized histamine. An increase in pulmonary resistance (RL) from 2.5 +/- 0.3 cmH2O . 1-1 . s (mean, +/- 1 SE) to 12.3 +/- 0.9 cmH2 was(More)
We have recently shown that selective mu-opiate receptor agonists increase blood pressure and heart rate when injected into the anteroventral hypothalamus (AV3V) of the conscious rat, and that lesions of this area may worsen the effects of hypovolemia. These experiments suggested the possibility that mu-agonists might enhance cardiovascular recuperation(More)
Thermoneutral head-out water immersion (WI) of humans leads to a sustained elevation of cardiac output (QCO), while systemic VO2 is unchanged. However, the regional blood flow responses (Qr) to WI are largely unknown. In eight dogs anesthetized with pentobarbital sodium, relative to the control vertical position in air with the chest and abdomen upright(More)
This report describes a new method, the splay angle measures, to determine neuromuscular dysfunction. Splay angles are measured from a standard splay test and define hind limb orientation quantified, in degrees, by the paw strike of the hind limbs. We used mutant rats, presenting with a chronic central nervous system demyelinating disease, characterized by(More)
In the present study the effects of thyrotropin releasing hormone (TRH) and its stable analogue, CG3703, on cardiac output (thermodilution, Cardiomax) and regional blood flow (BF; directional pulsed Doppler technique) were investigated in hypovolemic hypotension in the rat. In urethan-anesthetized rats TRH (0.5 or 2 mg/kg ia) or CG3703 (0.05 or 0.5 mg/kg(More)
We performed single breath washouts in 14 dogs and 4 pigs using a gas mixture containing 5% helium (He) and 5% sulphur hexafluoride (SF6) with, and without, an end inspiratory breathhold. In dogs, the slope of the alveolar plateau was steeper for SF6 than for He, the difference decreasing after 20 sec of breathholding. In contrast, in pigs there was no(More)
This report describes a standardized training and sensory screening procedure which was used to obtain 7 separate lingual vibrotactile thresholds for each of 5 normal subjects during a 30-day interval. Baseline observations of lingual sensitivity were highly consistent and occurred within a narrow range of contractor displacements. The authors conclude that(More)