Elsa Friesen

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Vitamin K3 inhibits the conversion of benzo(a)pyrene to its more polar metabolites in an in vitro rat liver microsomal system. Vitamin K3 also inhibits benzo(a)pyrene metabolism in rat liver fragments and reduces its mutagenicity in the Ames test. Higher concentrations of vitamin K3 are required to comparably reduce benzo(a)pyrene metabolism when the(More)
ABSTRACT. The levels of the vitamin K-dependent clotting factors are markedly lower in the human fetus and newborn than in older infants and adults. Direct measurement of vitamin K1 in cord plasma records low or undetectable levels. This phenomenon, although the norm, is referred to as vitamin K deficiency and is a significant risk factor for hemorrhage in(More)
The in vitro recovery of three different dosage forms of carbamazepine (CBZ) when dispersed in gastric or intestinal fluids, in the presence or absence of Ensure was determined. An equivalent of 1 mg of pure CBZ from Tegretol 200 mg of conventional tablets, chewtablets of Tegretol 200-mg and Apo-carbamazepine (200-mg tablets) were dispersed in five(More)
By L. G. ISIIAELS, G. E. DELORY, L. HNATIUK AND E. FRIESEN T HE SERUM activity of phosphohexose isonsserase, the enszyme faeilitatinsg the coisversions of glucose-6-phosphate to fructose-6-plsosphate, has recetstly conse insto use as an inidex of tumor growth and nsetastatic disease. Bodanssky was able to demonsstrate increased serum isomerase activity ins(More)
Pharmacy directors of 126 Alberta Hospitals were sent a survey requesting information on their attitudes and hiring practices of residency graduates. Sixty completed surveys were returned for a response rate of 48 percent. Seventy percent of the directors indicated that completion of a residency program was a favourable prerequisite prior to hiring.(More)
2,4-D, an extensively used herbicide, was intentionally ingested by a 61-year-old woman. An initial serum 2,4-D concentration of 392 mg/L was measured. The prominent clinical feature was marked central nervous system depression; primary laboratory abnormalities were extreme elevation of creatine kinase activity, and transitory elevation of AST and lactate(More)
These studies were undertaken to investigate the use of a technique for "homing" of an alkylating agent to lymphocytes as an immunosuppressive approach to inhibit allograft rejection. Trenimon (Tr) was bound covalently to antithymocyte globulin (ATG) and the effects of the complex on peripheral blood cells, thymus cells, spleen cells, and on foreign skin(More)
A Canadian Society for Pharmaceutical Sciences (CSPS) discussion group was held on August 23, 1997 in Edmonton, Alberta to discuss issues surrounding the bioequivalence of narrow therapeutic range (NTR) drugs. Participants in the discussion presented on topics related to sources of variability attributed to subject, target patient response and manufacturing(More)
Agranulocytosis associated with spironolactone administration is described in a 57-year-old man. Four days after initiation of spironolactone, leukocyte counts decreased from 8.2 to 2.3 X 10(9)/L with 6% neutrophils. Spironolactone, domperidone, and prochlorperazine were discontinued. Domperidone and prochlorperazine were reintroduced and there was(More)