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Journals and Conferences
Etoposide is an antitumor agent currently in clinical use for the treatment of small cell lung cancer, testicular cancer and lymphomas. Since the introduction of etoposide in 1971, its mechanism of… (More)
1. We investigated the response to pressure (myogenic tone) and flow of rat mesenteric resistance arteries cannulated in an arteriograph which allowed the measurement of intraluminal diameter for… (More)
Twenty-four children (14 boys and 10 girls) with neurosecretory dysfunction, defined by a response greater than 10 ng/ml to two pharmacological tests, and 24-hour GH secretion less than 3 ng/ml/min,… (More)
The C-4 triisopropylphenylsulfonyl (TPS) group of the 2,3-dideoxyuridine derivative 2 is readily displaced in situ by nitrogen nucleophiles forming N-4 substituted ddC in acceptable yields.
Some "AZT-HEPT" and "ddC-HEPT" conjugates were designed, synthesized and evaluated for their anti-HIV activity.
To test the concept that HIV reverse transcriptase could be effectively inhibited by "mixed site inhibitors", a series of seven conjugates containing both a nucleoside analogue component (AZT 1, ddC… (More)