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Although the Web is almost omnipresent in many children’s lives, most children lack adequate Web searching skills as well as skills to process and critically evaluate Web information. In this article, we describe and evaluate an educational program that aimed at acquiring Web skills in the context of a content knowledge domain. Through a multiple case study(More)
Calcium-activated potassium (K(Ca)) channels are present throughout the central nervous system as well as many peripheral tissues. Activation of K(Ca) channels contribute to maintenance of the neuronal membrane potential and was shown to underlie the afterhyperpolarization (AHP) that regulates action potential firing and limits the firing frequency of(More)
This paper investigates the accessibility and attractiveness of different types of ICT applications in education for girls and boys and for pupils from families with an ethnic minority background and from the majority population in the Netherlands. A study was conducted in seven schools (primary and secondary). Data were collected on participation, ICT(More)
Introduction. This article reports on the adequacy and specific characteristics of 5th grade students' use of Web literacy skills and strategies after completing a programme in which these skills and strategies were the focus of attention. Method. Data were collected from twenty-one student pairs' Web use during six assignments, and recorded with help of(More)
This study reports on the effects of the combined use of an interactive whiteboard (IWB) and a virtual learning environment (VLE) on mathematics performance and motivation. Lessons taught with an IWB were made available on the VLE, so that they could be consulted regardless of time and place. Students’ mathematics performance was monitored during one school(More)
Parkinson's disease is one of the most common neurodegenerative disorders and several mutations in different genes have been identified to contribute to the disease. A loss of function parkin RING1 domain mutant (C289G) is associated with autosomal-recessive juvenile-onset Parkinsonism (AR-JP) and displays altered solubility and sequesters into aggregates.(More)
Expanded polyglutamine (polyQ) stretches in at least nine unrelated proteins lead to inherited neuronal dysfunction and degeneration. The expansion size in all diseases correlates with age at onset (AO) of disease and with polyQ protein aggregation, indicating that the expanded polyQ stretch is the main driving force for the disease onset. Interestingly,(More)
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