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Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition*
Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several immune complex diseases. Compstatin, a 13-residue peptide, is anExpand
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Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin*
Background: NAIP5 and NLRC4 induce an innate immune response to intracellular flagellin. Results: Flagellin fragments were identified that induce signaling-competent NAIP5-NLRC4 inflammasomes withExpand
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Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation.
Inflammasomes are high molecular weight protein complexes that play a crucial role in innate immunity by activating caspase-1. Inflammasome formation is initiated when molecules originating fromExpand
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Minimal length requirement for proteasomal degradation of ubiquitin‐dependent substrates
An erroneous transcriptional process, known as molecular misreading, gives rise to an alternative transcript of the ubiquitin B (UBB) gene. This transcript encodes the protein UBB+1, which comprisesExpand
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When less becomes more: optimization of protein expression in HEK293-EBNA1 cells using plasmid titration - a case study for NLRs.
Transient transfection of the human HEK293-EBNA1 cell line using polyethyleneimine is widely adopted for recombinant protein production. Whereas high expression of many targets is achieved,Expand
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Designing disorder
Protein tags of various sizes and shapes catalyze progress in biosciences. Well-folded tags can serve to solubilize proteins. Small, unfolded, peptide-like tags have become invaluable tools forExpand
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Structural and functional studies on Nod Like Receptors: insights into NAIP/NLRC4 inflammasome formation
Our immune system is under constant attack of invading pathogens. The initiation of an appropriate immune response that leads to clearance of these microorganisms and infected cells is dependent onExpand
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Structure of C3c in complex with compstatin reveals a new mechanism of complement inhibition
Bert Janssen - Conformational Complexity of Complement Component C3 60 Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to severalExpand
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