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21 Running title: Llama antibody fragments that neutralize HIV-1 22 Abstract word count: 243 Text word count: 7226 23 2 ABSTRACT 1 Members of the Camelidae family produce immunoglobulins devoid of light chains. We have 2 characterized variable domains of these heavy-chain antibodies, the VHH, from llamas 3 immunized with HIV-1 envelope protein gp120 in(More)
INTRODUCTION The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases, including rheumatoid arthritis (RA). ALX-0061 is a bispecific Nanobody® with a high affinity and potency for IL-6 receptor (IL-6R), combined with an extended half-life by targeting human serum albumin. We describe here the relevant(More)
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