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IRF6 is a mediator of Notch pro‐differentiation and tumour suppressive function in keratinocytes
While the pro‐differentiation and tumour suppressive functions of Notch signalling in keratinocytes are well established, the underlying mechanisms remain poorly understood. We report here thatExpand
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Human tumor nanoparticles induce apoptosis of pancreatic cancer cells
Exosomes are vesicles secreted by most hematopoietic cells on fusion of multivesicular endosomes with the plasma membrane. Many studies have reported that exosomes may also be released by tumorExpand
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Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro.
Aggressive melanoma cells can engage in a process termed vasculogenic mimicry (VM) that reflects the ability of tumor cells to express a multipotent, stem cell-like phenotype. Melanoma cellExpand
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Resveratrol increases iodide trapping in the rat thyroid cell line FRTL-5.
BACKGROUND Resveratrol, a polyphenol found in grapes, exhibits several beneficial health effects by its antioxidant, antiinflammatory, and chemopreventive properties. The aim of the present study wasExpand
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Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles
We previously reported that exosomal nanoparticles secreted by human pancreatic tumoral cell lines decrease tumoral cell proliferation through the mitochondria‐dependent apoptotic pathway, because ofExpand
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Exosomal Lipids Impact Notch Signaling and Induce Death of Human Pancreatic Tumoral SOJ-6 Cells
Exosomes are of increasing interest as alternative mode of cell-to-cell communication. We previously reported that exosomes secreted by human SOJ-6 pancreatic tumor cells induce (glyco)proteinExpand
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Targeting Notch signaling in pancreatic cancer
Importance of the field: With some 220,000 new cases/year in the world, pancreatic adenocarcinoma is the fourth highest cause of death by cancers. Among newly diagnosed patients about 210,000 willExpand
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In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase.
The relationship between cholesterol and atherosclerosis has gained wide credence and red wine polyphenols have been shown to have an anti-atherogenic activity. In the present in vitro studies, weExpand
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Protective effect of resveratrol against LPS-induced extracellular lipoperoxidation in AR42J cells partly via a Myd88-dependent signaling pathway.
Lipopolysaccharides (LPS) are major components of the cell wall of Gram negative bacteria implicated in the pathogenesis of bacterial infection. Resveratrol is a polyphenolic phytoalexin exhibitingExpand
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Abstract 4156: Detection of lung cancer from plasma using the biosignature of circulating microvesicles
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Circulating microvesicles (cMV) are cell-derived structures that are abundantly present in the blood. Tumor cells produceExpand