Elodie Ly

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This study aims to develop a new FT-IR spectral imaging of tumoral tissue permitting a better characterization of tumor heterogeneity and tumor/surrounding tissue interface. Infrared (IR) data were acquired on 13 biopsies of paraffin-embedded human skin carcinomas. Our approach relies on an innovative fuzzy C-means (FCM)-based clustering algorithm, allowing(More)
FTIR spectral imaging was applied on formalin-fixed paraffin-embedded biopsies from colon and skin cancerous lesions. These samples were deposited onto different substrates (zinc selenide and calcium fluoride respectively) and embedded using two types of paraffin. Formalin fixation followed by paraffin embedding is the gold standard in tissue storage. It(More)
This study aims to develop IR imaging of tumor tissues for generating an automated IR-based histology. Formalin-fixed paraffin-embedded xenografts of human colon carcinomas were analyzed. Chemometric and statistical multivariate treatments of spectral data permitted to probe the intrinsic chemical composition of tissues, directly from paraffinized sections(More)
Basal cell carcinoma (BCC) can sometimes lead, through a possible invasion of the dermis and the subcutaneous tissue, to serious local damage to the patient. Several histological types of BCC are reported, among them, the superficial, nodular and infiltrative forms. This study reports the use of polarized Raman microspectroscopy on the nodular and(More)
Non-melanoma skin cancer includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Bowen's disease. The differential diagnosis of these lesions is sometimes difficult and relies on the histopathological examination of surgical specimens. However, a precise differential diagnosis is crucial for an accurate therapy and thus better patient care.(More)
BACKGROUND The diagnosis of malignant melanoma is based upon the histological evaluation of the lesion. As such, the morphological interpretation relies on the expertise of a dermatopathologist. Infrared microimaging is emerging as a new powerful tool to investigate tissue biochemistry. Infrared spectra probe the biochemical constitution of the sample and(More)
Polarized Raman microspectroscopy can provide precious information regarding the orientation and ordering of the molecules in a sample without staining or particular preparation. This technique is used for the first time on a human skin section to probe the molecular modifications of the surrounding dermis in superficial basal cell carcinoma. Spectra using(More)
  • Y D Av O R E N, A N N E D O H E R T Y, E U G E N E B R E E N, J O H N S H E E H A N A N D B R, E N Da, E L Ly
  • 2009
To explore clinical indications for, and results of, brain imaging in general adult psychiatry.We reviewed the 100 most recent uses of brain imaging on in-patients at the RESULTS Patients were of a mean age of 55.3 years. The most common indications for brain scans were cognitive impairment (33%) and other neuro-logical concerns (e.g. seizures; 30%).(More)
They thus present numerous evolutionary novelties, including differences in fundamental cell biology (their lack of an organelle called the apicoplast is one example), in their infectious cycle, and in their genome, which at around 3,950 genes is much smaller than that of other apicomplexans 5–7. The Cryptosporidium genome contains several essential genes(More)