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Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.
The Fanconi anemia (FA) core complex member FANCM remodels synthetic replication forks and recombination intermediates. Thus far, only one FA patient with FANCM mutations has been described, but theExpand
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Fancf‐deficient mice are prone to develop ovarian tumours
Fanconi anaemia (FA) is a rare recessive disorder marked by developmental abnormalities, bone marrow failure, and a high risk for the development of leukaemia and solid tumours. The inactivation ofExpand
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Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of Lynch syndrome.
BACKGROUND & AIMS Lynch syndrome, a nonpolyposis form of hereditary colorectal cancer, is caused by inherited defects in DNA mismatch repair (MMR) genes. Most patients carry a germline mutation in 1Expand
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In vivo significance of the G2 restriction point.
Loss of activity of the retinoblastoma pathway is a common event in human cancer. Mouse models have revealed that tumorigenesis by loss of Rb was accelerated by concomitant loss of the cell cycleExpand
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RB family tumor suppressor activity may not relate to active silencing of E2F target genes.
The retinoblastoma protein pRB and its two homologs p130 and p107 form the family of pocket proteins and play a major role in cell-cycle regulation and suppression of human and mouse tumorigenesis.Expand
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Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. However, weExpand
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Loss of p 53 suppresses replication-stress-induced 1 DNA breakage in G 1 / S checkpoint deficient cells 2 3
26 27 In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the 28 latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. 29Expand
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In vivo Significance of the G 2 Restriction Point
Loss of activity of the retinoblastoma pathway is a common event in human cancer. Mouse models have revealed that tumorigenesis by loss of Rb was accelerated by concomitant loss of the cell cycleExpand
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PO-005 Prevention strategies for intestinal cancer development in lynch syndrome
Introduction Lynch syndrome (LS) is an autosomal dominant hereditary cancer predisposition syndrome which is mostly caused by defects in DNA mismatch repair (MMR) genes MLH1 and MSH2. LS patientsExpand