Ellis L Rolett

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The relationship between cerebral interstitial oxygen tension (Pt(O(2))) and cellular energetics was investigated in mechanically ventilated, anesthetized rats during progressive acute hypoxia to determine whether there is a "critical" brain Pt(O(2)) for maintaining steady-state aerobic metabolism. Cerebral Pt(O(2)), measured by electron paramagnetic(More)
Cardiac performance is normally determined by architectural, cellular, and molecular structures that determine the heart's form, and by physiological and biochemical mechanisms that regulate the function of these structures. Impaired adaptation of form to function in failing hearts contributes to two syndromes initially called systolic heart failure (SHF)(More)
During exercise K+ is released from contracting muscle and plasma K+ concentration rises. Because beta 2-adrenergic agonists stimulate K+ uptake by skeletal muscle in vitro, we tested whether terbutaline, a selective beta 2-agonist, would reduce the loss of K+ from working muscle. Dynamic quadriceps muscle exercise was performed by 12 healthy male(More)
T HE sympathomimetic amine l-norepinephrine is extensively used in the treatment of hypotensive states, and is considered by many to be the pressor agent of choice.1-3 Shock associated with myocardial infarction is one of the more important of these hypotensive states.4-8 Therefore, it seemed relevant to examine the effects of infusion of this agent upon(More)
This study was performed to investigate the two-dimensional unprocessed radiofrequency (rf) ultrasonic backscatter from myocardium throughout the cardiac cycle. Eleven mongrel dogs underwent left lateral thoracotomy and had two-dimensional echocardiographic studies performed using a 5 MHz transducer. Regions of interest, selected to encompass a portion of(More)
The effects of the paramagnetic oxygen sensing material, lithium phthalocyanine (LiPc) and fusinite were assessed in the brain of Mongolian gerbils and the spinal columns of rats respectively, to determine if there are histologically discernible changes in the tissue surrounding the probe material. This information is essential for the evaluation of the(More)
Rolett, Ellis L., Ali Azzawi, Ke Jian Liu, Martin N. Yongbi, Harold M. Swartz, and Jeff F. Dunn. Critical oxygen tension in rat brain: a combined P-NMR and EPR oximetry study. Am J Physiol Regulatory Integrative Comp Physiol 279: R9–R16, 2000.—The relationship between cerebral interstitial oxygen tension (PtO2) and cellular energetics was investigated in(More)