Elliott E. Winters

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Gene regulation at functional elements (e.g., enhancers, promoters, insulators) is governed by an interplay of nucleosome remodeling, histone modifications, and transcription factor binding. To enhance our understanding of gene regulation, the ENCODE Consortium has generated a wealth of ChIP-seq data on DNA-binding proteins and histone modifications. We(More)
The advent of high-throughput DNA sequencing has enabled the measurement of many types of chemical phenomena in the human genome [2]. These methods have enabled the location of both punctate phenomena, such as transcription factor binding sites (TFBSs), and broad phenomena, such as the location of chemical modification of the histone proteins that wrap DNA.(More)
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