Elliot V. Plotkin

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An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparently healthy donors. A weak correlation (r(More)
Redox proteins catalyse the reactions of a wide variety of otherwise intractable substrates, such as dinitrogen, alkanes, arenes, terpenes and steroids. Two major factors impede the utilization of these enzymes--the inefficient electron transfer between the enzyme and electrode, and the properties often, but not inevitably, associated with enzymes, such as(More)
BP4 is a prototype carcinogenic polycychic aromatic hydrocarbon and is a ubiquitous environmental pollutant (28) which may cause cancer in humans. BP or its metabo lites are cytotoxic and mutagenic in mammalian cells (19, 20) and bacteria (2) and cause mammalian cell transforma tion and toxicity (3, 4, 13, 19). BP is metabolized to epoxides (15, 36),(More)
High-pressure liquid chromatography was used to analyze the rate of benzo(a)pyrene metabolite formation by liver microsomes from control and 3-methylcholanthrene-treated rats. The relative amounts of each metabolite formed were determined with several concentrations of microsomal mixed-function oxidases. The specific activity, i.e., amount formed per mg(More)
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