Elliot D. Menschik

Learn More
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of cognitive function whose cellular pathology and molecular etiology have been increasingly and dramatically unraveled over the last several years. Despite this substantial knowledge base, the disease remains poorly understood due to a basic lack of understanding of how memories are(More)
s of the 6th Annual Conference on Computational<lb>Neuroscience, Big Sky, Montana. Curcio, C. A. and Kemper, T. (1984) Nucleus raphe dorsalis in<lb>dementia of the Alzheimer type: neurofibrillary changes and<lb>neuronal packing density. J Neuropathol Exp Neurol, 43: 359-<lb>368. Davies, P. and Maloney, A. J. (1976) Selective loss of central<lb>cholinergic(More)
The sharing of radiologic images has become a fundamental part of radiology services and is essential for delivering high-quality care. Film is quickly becoming obsolete as a means of transporting and sharing large volumes of imaging data. Image sharing has evolved from film to transportable media (eg, compact disks) to direct electronic exchange over the(More)
One advantage of cortical synchronization as a binding mechanism is its ability to account for phenomena such as perceptual grouping. Such a mechanism requires the ability to synchronize groups of cells and to desynchronize these groups from each other. We present a striate cortical model of perceptual grouping in which synchronization and desynchronization(More)
Autoassociative attractor neural networks1,2 provide a powerful paradigm for the storage and recall of memories, however, their biological plausibility has always remained in question. Given the complexity and variability of biological networks, it seems likely that a “biological” attractor network must be regulated by some control structure. We describe a(More)
The purpose of this research was to develop queries that quantify the utilization of comparison imaging in free-text radiology reports. The queries searched for common phrases that indicate whether comparison imaging was utilized, not available, or not mentioned. The queries were iteratively refined and tested on random samples of 100 reports with human(More)
The hippocampus is known to be a critical structure for memory function, but how its anatomical, physiological, and cellular elements endow it with this function remains a mystery. As such, even less is known about how neuropathological changes associated with Alzheimer’s disease, epilepsy or traumatic brain injury lead to the clinical manifestations of(More)
We investigate the e!ects of cellular-level cholinergic neuromodulation on the physiological properties of a realistic, anatomically reconstructed CA3 pyramidal cell model. The model has 385-compartments, contains a wide variety of ion channels (Na, K DR , K C , K A , K M , K AHP , Ca L , Ca N , Ca T ), calcium di!usion, bu!ering and pumping, and represents(More)
  • 1