Ellena L. Badrick

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AIMS To determine the biological and behavioural factors linking work stress with coronary heart disease (CHD). METHODS AND RESULTS A total of 10 308 London-based male and female civil servants aged 35-55 at phase 1 (1985-88) of the Whitehall II study were studied. Exposures included work stress (assessed at phases 1 and 2), and outcomes included(More)
CONTEXT Evidence for an association of smoking status with cortisol secretion is mixed. OBJECTIVE The objective of the study was to assess the relationship between smoking status and salivary cortisol. DESIGN This was a cross-sectional study of smoking status and cortisol secretion from phase 7 (2002-2004) of the Whitehall II study. SETTING An(More)
Positive affective states are associated with favorable health outcomes, but the underlying mechanisms are poorly understood. The authors assessed associations between positive affect, cortisol sampled over the day, and inflammatory markers (C-reactive protein and interleukin-6) among 2,873 healthy members of the Whitehall II study. Data for this study were(More)
CONTEXT Evidence for an association between alcohol consumption and activity of the hypothalamic-pituitary-adrenal (HPA) axis is inconclusive. OBJECTIVE Our objective was to assess the relationship between indices of alcohol consumption and salivary cortisol concentration. DESIGN This was a cross-sectional study of alcohol consumption and cortisol(More)
CONTEXT The association of short sleep duration with cortisol secretion has not been thoroughly examined in large community dwelling populations and the relative importance of short sleep duration and sleep disturbance is unclear. OBJECTIVE The objective of the study was to assess the relationships between self-reported sleep duration, sleep disturbance,(More)
Patterns of psychological coping are associated with a variety of health outcomes but the underlying pathways are not yet established. The purpose of this study was to assess the relationship between salivary cortisol output over the course of a day and coping style. Data were available from 350 men and 192 women with an average age of 60.9 years.(More)
The evidence on the association between pioglitazone use and bladder cancer is contradictory, with many studies subject to allocation bias. The aim of our study was to examine the effect of exposure to pioglitazone on bladder cancer risk internationally across several cohorts. The potential for allocation bias was minimised by focusing on the cumulative(More)
OBJECTIVE To examine whether dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis associated with disadvantaged social position in working populations also occurs in older age groups. METHODS This study examines the association of several indicators of social position with two measures of cortisol secretion, a product of the HPA axis. We(More)
OBJECTIVE To determine whether ethnic group differences in glycated haemoglobin (HbA1c) changed over a 5-year period in people on medication for type 2 diabetes. DESIGN Open cohort in 2004-9. SETTING Electronic records of 100 of the 101 general practices in two inner London boroughs. PARTICIPANTS People aged 35 to 74 years on medication for type 2(More)
The association between fatigue and reduced activity in the hypothalamo-pituitary-adrenal (HPA) axis has been described. However the temporal association between fatigue and HPA activity is under debate. We examine whether alterations in cortisol secretion play a role in the development of fatigue or whether changes occur later as a consequence of fatigue(More)