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Injury, stimulation or training can induce changes in the homuncular organization of primary somatosensory (S1) and motor cortex (M1)1–6. Phantom limb pain was identified as a perceptual correlate of this cortical reorganization2,7. Using functional magnetic resonance imaging (fMRI), we found that enhanced use of a myoelectric prosthesis in upper extremity(More)
The efficacy of oral retarded morphine sulphate (MST) was tested against placebo in a double-blind crossover design in 12 patients with phantom limb pain after unilateral leg or arm amputation. Two counterbalanced treatment phases of 4 weeks each were initiated with an intravenous test infusion of MST or Placebo. The titration phase was 2 weeks. The dose of(More)
The extent of the cortical somatotopic map and its relationship to phantom phenomena was tested in five subjects with congenital absence of an upper limb, four traumatic amputees with phantom limb pain and five healthy controls. Cortical maps of the first and fifth digit of the intact hand, the lower lip and the first toe (bilaterally) were obtained using(More)
Operant conditioning mechanisms have been demonstrated to be important in the development of chronic pain behavior, but it is not clear whether and how this extends to pain perception itself. The fear-avoidance theory suggests that hypersensitivity may be induced by anticipatory pain avoidance learned through negative reinforcement by acute reductions of(More)
Es wird ein strukturiertes Interview zur Erfassung der Qualität, Quantität und zeitlichen Entwicklung schmerzhafter und nichtschmerzhafter Phantom- und Stumpfphänomene nach Amputation vorgestellt. Das Interview wurde an einer Stichprobe von 139 einseitig arm- oder beinamputierten Patienten auf seine Faktorenstruktur, Reliabilität und Validität hin(More)
The neuroscientific research of the past years has shown that extensive plastic change occurs in the adult human brain. The functional reorganization of the somatosensory and motor maps related to phantom limb pain is described. Subsequent to deafferentation amputees with phantom limb pain show a shift of neighbouring representation zones into the(More)
RESEARCH QUESTION A structured German-language interview was developed for the assessment of painful and non-painful phantom and stump phenomena after amputation. The aim was a thorough assessment of the quality, quantity and time course of these phenomena, which is of scientific as well as therapeutic relevance. METHODS Each phenomenon was assessed using(More)
Die neurowissenschaftliche Forschung der letzten Jahre erbrachte den Nachweis, dass im adulten menschlichen Gehirn erhebliche neuroplastische Veränderungen auftreten können. Am Beispiel des Phantomschmerzes wird die funktionelle kortikale Reorganisation im somatosensorischen und motorischen System beschrieben. Nach Deafferenzierung tritt bei Amputierten(More)
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