Ellen W. Clayton

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The American College of Medical Genetics and Genomics recently issued recommendations for reporting incidental findings from clinical whole-genome sequencing and whole-exome sequencing. The recommendations call for evaluating a specific set of genes as part of all whole-genome sequencing/whole-exome sequencing and reporting all pathogenic variants(More)
As more research studies incorporate next-generation sequencing (including whole-genome or whole-exome sequencing), investigators and institutional review boards face difficult questions regarding which genomic results to return to research participants and how. An American College of Medical Genetics and Genomics 2013 policy paper suggesting that(More)
OBJECTIVES Improvements in electronic health record (EHR) system development will require an understanding of psychiatric clinicians' views on EHR system acceptability, including effects on psychotherapy communications, data-recording behaviors, data accessibility versus security and privacy, data quality and clarity, communications with medical colleagues,(More)
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem and often long-lasting disorder , with manifestations that can cause substantial morbidity and can severely impair patients' health and well-being. It is estimated that between 836 000 and 2.5 million individuals are affected in the United States. 1,2 Patients with ME/CFS are(More)
Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highly-detailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including personalized medical services. While the benefits of the genomics revolution are trumpeted by the biomedical community, the(More)
The advent and refinement of sequencing technologies has resulted in a decrease in both the cost and time needed to generate data on the entire sequence of the human genome. This has increased the accessibility of using whole-genome sequencing and whole-exome sequencing approaches for analysis in both the research and clinical contexts. The expectation is(More)
Given the potential wealth of insights in personal data the big databases can provide, many organizations aim to share data while protecting privacy by sharing de-identified data, but are concerned because various demonstrations show such data can be re-identified. Yet these investigations focus on how attacks can be perpetrated, not the likelihood they(More)
  • Joanna L Grossman, Grossman My, Deborah Brake, Ellen Wright Clayton, Grant Hayden, Herma Hill Kay +2 others
  • 2010
I appreciate the many good questions and comments posed during these various presentations. " Certain attitudes about pregnancy and childbirth, throughout human history, have sustained pervasive, often law-sanctioned, restrictions on a woman's place among paid workers and active citizens. " 1 INTRODUCTION
Recently, two Japanese clinical studies of antihypertensive drugs, supported by pharmaceutical companies and published in the Lancet by groups of Japanese investigators, were later withdrawn by the Swiss company Novartis that supported one of the studies, but conducted by different Japanese research groups, were later found to be tainted by misconduct(More)
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