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Immunoglobulin variable region exons are assembled in developing B cells by V(D)J recombination. Once mature, these cells undergo class-switch recombination (CSR) when activated by antigen. CSR changes the heavy chain constant region exons (Ch) expressed with a given variable region exon from Cmu to a downstream Ch (for example, Cgamma, Cepsilon or Calpha),(More)
The Problem Frames approach defines identifiable problem classes based on, among other things, their context and the characteristics of their domains, interfaces and requirements, without going deeply into the solution. Other software engineering approaches deal with the concept of patterns that present well-known solutions, such as archetype, analysis and(More)
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