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Quantum dot bioconjugates for imaging, labelling and sensing.

• Igor L. Medintz, H. Tetsuo Uyeda, Ellen R. Goldman, Hedi Mattoussi
• Nature materials
• 2005

One of the fastest moving and most exciting interfaces of nanotechnology is the use of quantum dots (QDs) in biology. The unique optical properties of QDs make them appealing as in vivo and in vitro… (More)

Self-assembled nanoscale biosensors based on quantum dot FRET donors.

• Igor L. Medintz, Aaron R. Clapp, Hedi Mattoussi, Ellen R. Goldman, Brent Fisher, J. Matthew Mauro
• Nature materials
• 2003

The potential of luminescent semiconductor quantum dots (QDs) to enable development of hybrid inorganic-bioreceptor sensing materials has remained largely unrealized. We report the design, formation… (More)

Multiplexed toxin analysis using four colors of quantum dot fluororeagents.

• Ellen R. Goldman, Aaron R. Clapp, +4 authors Hedi Mattoussi
• Analytical chemistry
• 2004

Quantum dots (QDs) have the potential to simplify the performance of multiplexed analysis. In this work, we prepared bioinorganic conjugates made with highly luminescent semiconductor nanocrystals… (More)

Facile generation of heat-stable antiviral and antitoxin single domain antibodies from a semisynthetic llama library.

• Ellen R. Goldman, George P. Anderson, +5 authors Andrew Hayhurst
• Analytical chemistry
• 2006

Llamas possess a class of unconventional immunoglobulins that have only heavy chains; unpaired heavy variable domains are responsible for antigen binding. These domains have previously been cloned… (More)

Development of antiricin single domain antibodies toward detection and therapeutic reagents.

• George P. Anderson, Jinny L. Liu, +4 authors Ellen R. Goldman
• Analytical chemistry
• 2008

Single domain antibodies (sdAb) that bind ricin with high affinity and specificity were selected from a phage display library derived from the mRNA of heavy chain antibodies obtained from lymphocytes… (More)

A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensor.

• Ellen R. Goldman, Igor L. Medintz, +6 authors Hedi Mattoussi
• Journal of the American Chemical Society
• 2005

We demonstrate the use of luminescent QDs conjugated to antibody fragments to develop solution-phase nanoscale sensing assemblies, based on fluorescence resonance energy transfer (FRET) for the… (More)

Use of quantum dots for live cell imaging

• Jyoti K Jaiswal, Ellen R. Goldman, Hedi Mattoussi, Sanford M Simon
• Nature Methods
• 2004

Monitoring interactions within and among cells as they grow and differentiate is a key to understanding organismal development. Fluorescence microscopy is among the most widely used approaches for… (More)

Capping of CdSe–ZnS quantum dots with DHLA and subsequent conjugation with proteins

• Aaron R. Clapp, Ellen R. Goldman, Hedi Mattoussi
• Nature Protocols
• 2006

We provide a detailed protocol for designing water-soluble CdSe–ZnS quantum dots (QDs) based on cap exchange of the native hydrophobic shell with dihydrolipoic acid (DHLA) ligands, and the… (More)

Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response.

• Nadia Anikeeva, Tatiana Lebedeva, +4 authors Yuri Sykulev
• Proceedings of the National Academy of Sciences…
• 2006

Cytotoxic T lymphocytes (CTL) can respond to a few viral peptide-MHC-I (pMHC-I) complexes among a myriad of virus-unrelated endogenous self pMHC-I complexes displayed on virus-infected cells. To… (More)

Avidin: a natural bridge for quantum dot-antibody conjugates.

• Ellen R. Goldman, Eric D Balighian, +4 authors George P. Anderson
• Journal of the American Chemical Society
• 2002

We describe the preparation and characterization of bioinorganic conjugates in which luminescent semiconductor CdSe-ZnS core-shell nanocrystal quantum dots (QDs) were coupled to antibodies through… (More)

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