Ellen M. Gibson

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BACKGROUND AND PURPOSE Motor recovery after ischemic stroke in primary motor cortex is thought to occur in part through training-enhanced reorganization in undamaged premotor areas, enabled by reductions in cortical inhibition. Here we used a mouse model of focal cortical stroke and a double-lesion approach to test the idea that a medial premotor area(More)
BACKGROUND Owing to a reported learning effect in patients with chronic cardiopulmonary disease, performance of at least two six-minute walk tests (6MWT) are recommended as standard practice. Patients with chronic heart failure (CHF) are typically elderly and frail and it is unknown whether current guidelines are practical in a clinical setting. AIMS The(More)
BACKGROUND AND PURPOSE Data from both humans and animal models suggest that most recovery from motor impairment after stroke occurs in a sensitive period that lasts only weeks and is mediated, in part, by an increased responsiveness to training. Here, we used a mouse model of focal cortical stroke to test 2 hypotheses. First, we investigated whether(More)
BACKGROUND AND OBJECTIVE Prior studies have suggested that after stroke there is a time-limited period of increased responsiveness to training as a result of heightened plasticity-a sensitive period thought to be induced by ischemia itself. Using a mouse model, we have previously shown that most training-associated recovery after a caudal forelimb area(More)
  • Annette Flanagin, Brenda Gregoline, +103 authors Nathan Mitre
  • JAMA otolaryngology-- head & neck surgery
  • 2016
Executive Editor Phil B. Fontanarosa, MD, MBA Executive Managing Editor Annette Flanagin Managing Editor Brenda Gregoline Deputy Managing Editor Lauren Fischer Senior Manuscript Editors Karen L. Boyd, John McFadden Manuscript Editors Gabriel Dietz, Rochelle C. Lodder, Sam Wilder Freelance Manuscript Editing Manager Diane L. Cannon Freelance Manuscript(More)
Steven R. Zeiler, Ellen M. Gibson, Robert E. Hoesch, Ming Y. Li, Paul F. Worley, Richard J. Recovery in a Mouse Model of Focal Stroke Medial Premotor Cortex Shows a Reduction in Inhibitory Markers and Mediates Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American(More)
Background and objective. Prior studies have suggested that after stroke there is a time-limited period of increased responsiveness to training as a result of heightened plasticity—a sensitive period thought to be induced by ischemia itself. Using a mouse model, we have previously shown that most training-associated recovery after a caudal forelimb area(More)
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