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BACKGROUND AND PURPOSE Motor recovery after ischemic stroke in primary motor cortex is thought to occur in part through training-enhanced reorganization in undamaged premotor areas, enabled by reductions in cortical inhibition. Here we used a mouse model of focal cortical stroke and a double-lesion approach to test the idea that a medial premotor area(More)
BACKGROUND AND PURPOSE Data from both humans and animal models suggest that most recovery from motor impairment after stroke occurs in a sensitive period that lasts only weeks and is mediated, in part, by an increased responsiveness to training. Here, we used a mouse model of focal cortical stroke to test 2 hypotheses. First, we investigated whether(More)
BACKGROUND AND OBJECTIVE Prior studies have suggested that after stroke there is a time-limited period of increased responsiveness to training as a result of heightened plasticity-a sensitive period thought to be induced by ischemia itself. Using a mouse model, we have previously shown that most training-associated recovery after a caudal forelimb area(More)
483 W ith improved acute care, more patients with ischemic stroke survive and up to 60% of them have disability in arm or leg use, and up to one third need placement in a long-term care facility. 1 In addition to the personal impact, the economic cost of disability translates to more than $30 billion in annual care. 2 Most recovery at both the impairment(More)
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