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A monoclonal antibody (RT97) against neurofilament protein specifically and exclusively labelled a subpopulation of rat dorsal root ganglion (DRG) neurones. For seven ganglia (L4 and T13) studied quantitatively the frequency distribution histograms of the size of labelled cells could be fitted by a single normal distribution whose parameters were extremely(More)
Conventional antibodies have long been used in an attempt to produce specific neural markers. Such markers would be invaluable for studying the structural organization and development of the nervous system. Unfortunately, they have not been found to discriminate satisfactorily between neuronal subpopulations. Recent developments of the hybridoma technique,(More)
A panel of monoclonal antibodies was systematically applied to cerebrospinal fluid from 17 patients with suspected neoplastic meningitis and the results were compared with those obtained from routine cytological preparations. The antibody panel consisted of markers for neuroectodermal tissue ( UJ13A ), epithelial cytokeratin ( LE61 ), leucocytes ( 2D1 ),(More)
This paper reviews the diagnostic role of monoclonal antibody immunohistochemistry in a series of 189 brain tumour biopsies and 22 cases of neoplastic meningitis. The diagnostic monoclonal antibody panel, which includes markers for glial, neural, epithelial and lymphoid differentiation antigens, was used to test a wide variety of cerebral and spinal tumours(More)
Monoclonal antibody 2C5 labels a subset of dorsal root ganglion neurones in the rat. The cell sizes of these neurones fall within the range for the small dark cell population and the antibody labels between a half and two-thirds of the neurones in this size range. A subpopulation of small neurones was also labelled in the trigeminal and vagal ganglia. Other(More)
In the United States and globally, healthcare delivery is in the midst of an acute transformation with the adoption and use of health information technology (health IT) thus generating increasing amounts of patient care data available in computable form. Secure and trusted use of these data, beyond their original purpose can change the way we think about(More)
Nurses represent the largest proportion of direct healthcare providers. Overstaffed or understaffed units will have implications for the quality, cost, patient, and nurse satisfaction. It is vital that nurses are armed with appropriate instruments and data to help them plan and implement efficient and effective nursing teams. A compelling case is made for(More)
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