Ellen A. Schur

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Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypothalamic inflammatory signaling was evident in both rats and(More)
Considerable overlap in symptoms and disease comorbidity has been noted among medically unexplained and psychiatric conditions seen in the primary care setting, such as chronic fatigue syndrome, low back pain, irritable bowel syndrome, chronic tension headache, fibromyalgia, temporomandibular joint disorder, major depression, panic attacks, and(More)
BACKGROUND Neuronal processes that underlie the subjective experience of satiety after a meal are not well defined. OBJECTIVE We investigated how satiety alters the perception of and neural response to visual food cues. DESIGN Normal-weight participants (10 men, 13 women) underwent 2 fMRI scans while viewing images of high-calorie food that was(More)
OBJECTIVE To develop a non-invasive method of studying brain mechanisms involved in energy homeostasis and appetite regulation in humans by using visual food cues that are relevant to individuals attempting weight loss. DESIGN Functional magnetic resonance imaging (fMRI) was used to compare brain activation in regions of interest between groups of food(More)
OBJECTIVE To determine if shared genetic or environmental vulnerabilities could underlie depression and migraine. BACKGROUND Depression and migraine headaches frequently coexist and their comorbidity may be due to shared etiologies. METHODS Female twins in the University of Washington Twin Registry responded to a mailed survey regarding their health(More)
OBJECTIVE To develop a broader understanding of young children's knowledge and beliefs about dieting and body dissatisfaction. METHOD Sixty-two third through sixth-grade boys and girls completed audiotaped interviews and questionnaires regarding eating behavior, attitudes toward dieting, and body dissatisfaction. RESULTS Fifty percent of all children(More)
Despite widespread efforts at weight loss, the prevalence of obesity continues to rise. Restrained eating is a pattern of attempted weight control characterized by cognitive restriction of food intake that has paradoxically been linked with overeating and/or weight gain. It is not known whether restrained eating is associated with abnormalities in(More)
Effective mentorship is likely one of the most important determinants of success in academic medicine and research. Many papers focus on mentoring from the mentor's perspective, but few give guidance to mentees forging these critically important relationships. The authors apply "managing up," a corporate concept, to academic medical settings both to promote(More)
OBJECTIVE To use functional magnetic resonance imaging (fMRI) in craniopharyngioma (CP) patients to examine the hypothesis that hypothalamic damage due to CP and its treatment results in enhanced perception of food reward and/or impaired central satiety processing. METHODS Pre- and post-meal responses to visual food cues in brain regions of interest (ROI;(More)
Gliosis, the activation of astrocyte and microglial cell populations, is a hallmark of central nervous system injury and is detectable using either immunohistochemistry or in vivo magnetic resonance imaging (MRI). Obesity in rodents and humans is associated with gliosis of the arcuate nucleus, a key hypothalamic region for the regulation of energy(More)