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Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
Primary cilia interpret vertebrate Hedgehog (Hh) signals. Why cilia are essential for signaling is unclear. One possibility is that some forms of signaling require a distinct membrane lipidExpand
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Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis
Injured skeletal muscle regenerates, but with age or in muscular dystrophies, muscle is replaced by fat. Upon injury, muscle-resident fibro/adipogenic progenitors (FAPs) proliferated and gave rise toExpand
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Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision
The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent cells, the primary cilium insulates itself from contiguous dynamic membrane processes on the cellExpand
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The role of Tmem231 and Intu in transition zone organization and function
Author(s): Roberson, Elle Caitlin | Advisor(s): Reiter, Jeremy F | Abstract: Primary cilia are signaling organelles that project from the apical surface of almost all vertebrate cells. The signalingExpand
The mystery of assisted reproductive technologies.
One of the first steps towards a successful pregnancy is fertilization, where sperm and oocyte come together to form a zygote. In mammals, this process can occur in vitro, allowing assistedExpand
A Comparative Study of the Turnover of Multiciliated Cells in the Mouse Trachea, Oviduct and Brain
In mammals, multiciliated cells (MCCs) line the lumen of the trachea, oviduct, and brain ventricles, where they drive fluid flow across the epithelium. Each MCC population experiences vastlyExpand